November 23, 2009 ABC NIGHTLINE

Part 1

You can view this video right here by getting the latest version of Flash Player!

DOWNLOADS: (54)

PLAYS: (218)

Part 2

You can view this video right here by getting the latest version of Flash Player!

DOWNLOADS: (52)

PLAYS: (187)

In the "Nightline" interview, Hampton provides astonishing new details about the affair and its many repercussions, including the end of a close 20-year friendship between the two families and the loss of the Hamptons' jobs.

"Lost my job. Lost my best friend. Nearly lost my wife," he said on the ripple effect of Ensign's affair.

Hampton makes allegations of hypocrisy, hubris -- cover-ups and maybe even crimes -- that have destroyed lives and could destroy Ensign's political career.

"It's hard to comprehend what's still taking place, what's going on this moment, with regards to the unraveling of the choices and the decisions that John's made," Hampton said.

Hampton said he's finally speaking out because he wants Ensign held accountable.

"I think there are missing pieces to what's been reported," he said. "Important for people to understand what the senator has done. ... The truth needs to come out."

Ensign Once the Rising GOP Star

Ensign was a rising star in the Republican Party. During his second term, there were already rumblings that the junior senator from Nevada might be the party's next best hope for president.

Ensign was an attractive candidate: good-looking, from a wealthy Las Vegas family, with impeccable conservative credentials. "Born again" in college, Ensign was a loud and leading voice for lawmakers adhering to strict Christian family values. He argued passionately for the Federal Marriage Amendment and publicly condemned President Clinton during the Monica Lewinsky scandal and Sen. Larry Craig, R-Idaho, when he was accused of propositioning another man in a public restroom.

Read more at NIGHTLINE